error en iis 4.0 permisos asp net

dar permisos en aspnet 4.0 en w2003 server servive pack 2, la carpeta system 32 servivio de red

Server Error in '/' Application.

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Compilation Error

Description: An error occurred during the compilation of a resource required to service this request. Please review the following specific error details and modify your source code appropriately.

Compiler Error Message: CS0016: Could not write to output file 'c:\WINDOWS\Microsoft.NET\Framework\v4.0.30319\Temporary ASP.NET Files\root\c7e93ee8\2ebe6d4c\App_Code.8-lohqal.dll' -- 'Access is denied. '